Ginkgolides: selective acetylations, translactonization, and biological evaluation
Research output: Contribution to journal › Journal article › Research › peer-review
Stanislav Jaracz, Kristian Strømgaard, Koji Nakanishi
Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.
|Journal||Journal of Organic Chemistry|
|Number of pages||4|
|Publication status||Published - 28 Jun 2002|
- Acetates, Binding, Competitive, Catalysis, Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Ligands, Photoaffinity Labels, Platelet Activating Factor, Structure-Activity Relationship