Ginkgolides: selective acetylations, translactonization, and biological evaluation

Research output: Contribution to journalJournal articleResearchpeer-review

Stanislav Jaracz, Kristian Strømgaard, Koji Nakanishi

Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.
Original languageEnglish
JournalJournal of Organic Chemistry
Volume67
Issue number13
Pages (from-to)4623-4626
Number of pages4
ISSN0022-3263
DOIs
Publication statusPublished - 28 Jun 2002
Externally publishedYes

    Research areas

  • Acetates, Binding, Competitive, Catalysis, Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Ligands, Photoaffinity Labels, Platelet Activating Factor, Structure-Activity Relationship

ID: 45810405