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GPCRdb: an information system for G protein-coupled receptors

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Vignir Isberg, Stefan Mordalski, Christian Munk, Krzysztof Rataj, Kasper Harpsøe, Alexander S Hauser, Bas Vroling, Andrzej J Bojarski, Gert Vriend, David E Gloriam

Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.

Original languageEnglish
JournalNucleic Acids Research
Volume44
Issue numberD1
Pages (from-to)D356-64
ISSN0305-1048
DOIs
Publication statusPublished - 4 Jan 2016

Bibliographical note

FUNDING:
European Research Council [639125 to D.E.G]; Lundbeck
Foundation [R163-2013-16327 to D.E.G]; Danish Council
for Independent Research [1331-00180 to D.E.G]; Polish
National Science Centre [DEC-2014/12/T/NZ2/00529 to
S.M.]. Funding for open access charge: European Research
Council [639125 to D.E.G].

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