GPCRdb: The G protein-coupled receptor database - an introduction

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

GPCRdb: The G protein-coupled receptor database - an introduction. / Munk, C; Isberg, V; Mordalski, S; Harpsøe, K; Rataj, K; Hauser, A S; Kolb, P; Bojarski, A J; Vriend, G; Gloriam, D E.

In: British Journal of Pharmacology, Vol. 173, No. 14, 07.2016, p. 2195-207.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Munk, C, Isberg, V, Mordalski, S, Harpsøe, K, Rataj, K, Hauser, AS, Kolb, P, Bojarski, AJ, Vriend, G & Gloriam, DE 2016, 'GPCRdb: The G protein-coupled receptor database - an introduction', British Journal of Pharmacology, vol. 173, no. 14, pp. 2195-207. https://doi.org/10.1111/bph.13509

APA

Munk, C., Isberg, V., Mordalski, S., Harpsøe, K., Rataj, K., Hauser, A. S., ... Gloriam, D. E. (2016). GPCRdb: The G protein-coupled receptor database - an introduction. British Journal of Pharmacology, 173(14), 2195-207. https://doi.org/10.1111/bph.13509

Vancouver

Munk C, Isberg V, Mordalski S, Harpsøe K, Rataj K, Hauser AS et al. GPCRdb: The G protein-coupled receptor database - an introduction. British Journal of Pharmacology. 2016 Jul;173(14):2195-207. https://doi.org/10.1111/bph.13509

Author

Munk, C ; Isberg, V ; Mordalski, S ; Harpsøe, K ; Rataj, K ; Hauser, A S ; Kolb, P ; Bojarski, A J ; Vriend, G ; Gloriam, D E. / GPCRdb: The G protein-coupled receptor database - an introduction. In: British Journal of Pharmacology. 2016 ; Vol. 173, No. 14. pp. 2195-207.

Bibtex

@article{f3fb6ba3b7f34927bcd88fe7e5de11be,
title = "GPCRdb: The G protein-coupled receptor database - an introduction",
abstract = "GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single-point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross-referenced by GPCRdb and web servers with corresponding functionality.",
keywords = "Journal Article, Review",
author = "C Munk and V Isberg and S Mordalski and K Harps{\o}e and K Rataj and Hauser, {A S} and P Kolb and Bojarski, {A J} and G Vriend and Gloriam, {D E}",
note = "{\circledC} 2016 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.",
year = "2016",
month = "7",
doi = "10.1111/bph.13509",
language = "English",
volume = "173",
pages = "2195--207",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "14",

}

RIS

TY - JOUR

T1 - GPCRdb: The G protein-coupled receptor database - an introduction

AU - Munk, C

AU - Isberg, V

AU - Mordalski, S

AU - Harpsøe, K

AU - Rataj, K

AU - Hauser, A S

AU - Kolb, P

AU - Bojarski, A J

AU - Vriend, G

AU - Gloriam, D E

N1 - © 2016 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

PY - 2016/7

Y1 - 2016/7

N2 - GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single-point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross-referenced by GPCRdb and web servers with corresponding functionality.

AB - GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single-point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross-referenced by GPCRdb and web servers with corresponding functionality.

KW - Journal Article

KW - Review

U2 - 10.1111/bph.13509

DO - 10.1111/bph.13509

M3 - Journal article

VL - 173

SP - 2195

EP - 2207

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 14

ER -

ID: 163862845