Heart ischemia-reperfusion induces local upregulation of vasoconstrictor endothelin receptor type B in rat coronary arteries downstream of occlusion

Research output: Contribution to journalJournal articleResearchpeer-review

Gry Freja Skovsted, L.S. Kruse, R Larsen, A F Pedersen, S Trautner, Majid Sheykhzade, L Edvinsson

Endothelins act via two receptor subtypes, endothelin receptor type A (ETA ) and type B (ETB ). Under physiological conditions in coronary arteries ETA receptors expressed in smooth muscle cells mediate vasoconstriction whereas ETB receptors mainly found in endothelial cells mediate vasorelaxation. However, under pathophysiological conditions ETB receptors may also be expressed in vascular smooth muscle cells mediating vasoconstriction. We aimed to investigate whether vasoconstrictor ETB receptors are upregulated in coronary arteries after experimental myocardial ischemia in rats.
Original languageEnglish
JournalBritish Journal of Pharmacology
Volume171
Issue number11
Pages (from-to)2726-2738
Number of pages13
ISSN0007-1188
DOIs
Publication statusPublished - 28 Jan 2014

ID: 98988340