Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

Research output: Contribution to journalJournal articleResearchpeer-review

Anna Cecilia Jørgensen, Anette Seo Torstenson

The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.
Original languageEnglish
JournalPharmaceutical Development and Technology
Volume13
Issue number3
Pages (from-to)187-95
Number of pages8
ISSN1083-7450
DOIs
Publication statusPublished - 2008

Bibliographical note

Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction

ID: 9171914