Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

Research output: Contribution to journalJournal articleResearchpeer-review

Theis S Wilbek, Tine Skovgaard, Fiona J Sorrell, Stefan Knapp, Jens Berthelsen, Kristian Strømgaard

A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.
Original languageEnglish
JournalChemBioChem
Volume16
Issue number1
Pages (from-to)59-63
Number of pages5
ISSN1439-4227
DOIs
Publication statusPublished - 2 Jan 2015

ID: 138769080