Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium

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Louise Kjærulff, Anita Nielsen, Maria Mansson, Lone Gram, Thomas Ostenfeld Larsen, Hanne Ingmer, Charlotte Held Gotfredsen

During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans. The chemical fingerprint of the bacterium showed primarily non-ribosomal peptide synthetase (NRPS)-like compounds, including the known pyrrothine antibiotic holomycin and a wide range of peptides, from diketopiperazines to cyclodepsipeptides of 500-900 Da. Purification of components from the pellet fraction led to the isolation and structure elucidation of four new cyclodepsipeptides, ngercheumicin F, G, H, and I. The ngercheumicins interfered with expression of virulence genes known to be controlled by the agr quorum sensing system of Staphylococcus aureus, although to a lesser extent than the previously described solonamides from the same strain of Photobacterium.
Original languageEnglish
JournalMarine Drugs
Volume11
Issue number12
Pages (from-to)5051-5062
Number of pages12
ISSN1660-3397
DOIs
Publication statusPublished - 2013

ID: 99345285