IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes

Research output: Contribution to journalJournal articleResearchpeer-review

Sidsel Falkencrone, Lars K. Poulsen, Carsten Bindslev-Jensen, Anders Woetmann Andersen, Niels Ødum, Britta Cathrina Poulsen, L. Blom, B. M. Jensen, B. F. Gibbs, I. M. Yasinska, V. V. Sumbayev, P. S. Skov

IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume68
Issue number5
Pages (from-to)614-620
Number of pages7
ISSN0105-4538
DOIs
Publication statusPublished - 2013

ID: 45791918