Iminolactones from Schizophyllum commune
Research output: Contribution to journal › Journal article › Research › peer-review
Schizine A (1) and B (2) the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acids phenylalanine or tryptophan and an α-hydroxyketomniopetal. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.
|Journal||Journal of Natural Products|
|Number of pages||4|
|Publication status||Published - 2015|
- The Faculty of Health and Medical Sciences - Natural products, Iminolactones, Schizophyllum commune