Iminolactones from Schizophyllum commune

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Xuemei Liu, Karla Andrea Frydenvang, Huizhen Liu, Lin Zhai, Ming Chen, Carl Erik Olsen, Søren Brøgger Christensen

Schizine A (1) and B (2) the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acids phenylalanine or tryptophan and an α-hydroxyketomniopetal. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.
Original languageEnglish
JournalJournal of Natural Products
Volume78
Issue number5
Pages (from-to)1165-1168
Number of pages4
ISSN0974-5211
DOIs
Publication statusPublished - 2015

ID: 137476779