In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration. / Pedersen, Brian Thoning; Larsen, Susan Weng; Østergaard, Jesper; Larsen, Claus Selch.

In: Drug Delivery, Vol. 15, No. 1, 2008, p. 23-30.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, BT, Larsen, SW, Østergaard, J & Larsen, CS 2008, 'In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration', Drug Delivery, vol. 15, no. 1, pp. 23-30. https://doi.org/10.1080/10717540701828657

APA

Pedersen, B. T., Larsen, S. W., Østergaard, J., & Larsen, C. S. (2008). In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration. Drug Delivery, 15(1), 23-30. https://doi.org/10.1080/10717540701828657

Vancouver

Pedersen BT, Larsen SW, Østergaard J, Larsen CS. In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration. Drug Delivery. 2008;15(1):23-30. https://doi.org/10.1080/10717540701828657

Author

Pedersen, Brian Thoning ; Larsen, Susan Weng ; Østergaard, Jesper ; Larsen, Claus Selch. / In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration. In: Drug Delivery. 2008 ; Vol. 15, No. 1. pp. 23-30.

Bibtex

@article{3d6283f0e9d311dcbee902004c4f4f50,
title = "In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration",
abstract = "In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspensions have been compared and the sustained release properties from such suspensions formed in situ has been evaluated. The appearance of lidocaine in the acceptor phase after instillation of preformed and in situ formed aqueous and oil suspensions into the small aqueous donor compartment applied to zero-order kinetics as long sufficient amounts of solid lidocaine remained in the donor cell. The obtained data indicate that oil solutions and oil suspensions of lidocaine possess prolonged release properties equal to or better than those of aqueous counterparts. Also the release properties of preformed aqueous and oil suspensions are identical to such suspension types formed in situ. The present in vitro model appears useful in quality control and formulation development in the field of parenteral depots.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Pedersen, {Brian Thoning} and Larsen, {Susan Weng} and Jesper {\O}stergaard and Larsen, {Claus Selch}",
year = "2008",
doi = "10.1080/10717540701828657",
language = "English",
volume = "15",
pages = "23--30",
journal = "Drug Delivery",
issn = "1071-7544",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration

AU - Pedersen, Brian Thoning

AU - Larsen, Susan Weng

AU - Østergaard, Jesper

AU - Larsen, Claus Selch

PY - 2008

Y1 - 2008

N2 - In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspensions have been compared and the sustained release properties from such suspensions formed in situ has been evaluated. The appearance of lidocaine in the acceptor phase after instillation of preformed and in situ formed aqueous and oil suspensions into the small aqueous donor compartment applied to zero-order kinetics as long sufficient amounts of solid lidocaine remained in the donor cell. The obtained data indicate that oil solutions and oil suspensions of lidocaine possess prolonged release properties equal to or better than those of aqueous counterparts. Also the release properties of preformed aqueous and oil suspensions are identical to such suspension types formed in situ. The present in vitro model appears useful in quality control and formulation development in the field of parenteral depots.

AB - In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspensions have been compared and the sustained release properties from such suspensions formed in situ has been evaluated. The appearance of lidocaine in the acceptor phase after instillation of preformed and in situ formed aqueous and oil suspensions into the small aqueous donor compartment applied to zero-order kinetics as long sufficient amounts of solid lidocaine remained in the donor cell. The obtained data indicate that oil solutions and oil suspensions of lidocaine possess prolonged release properties equal to or better than those of aqueous counterparts. Also the release properties of preformed aqueous and oil suspensions are identical to such suspension types formed in situ. The present in vitro model appears useful in quality control and formulation development in the field of parenteral depots.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1080/10717540701828657

DO - 10.1080/10717540701828657

M3 - Journal article

VL - 15

SP - 23

EP - 30

JO - Drug Delivery

JF - Drug Delivery

SN - 1071-7544

IS - 1

ER -

ID: 2998544