Isolation of a library of aromadendranes from Landolphia dulcis and its characterization using the VolSurf approach

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Dan Staerk, Brian Skole, Flemming Steen Jørgensen, Bogdan A Budnik, Patrick Ekpe, Jerzy W Jaroszewski

A library of nine aromadendrane-type sesquiterpenes (1-9), including eight new natural products (1-5 and 7-9), was isolated from Landolphia dulcis var. barteri along with a previously described cadinane derivative (10) and a new muurolane derivative (11). The structures of all compounds were established by means of NMR methods including COSY, NOESY, HSQC, and HMBC experiments, supported by HRMS and optical rotation data. Virtual characterization of the aromadendrane library (1-9) was performed using chemoinformatics tools. 3D molecular fields were calculated with the GRID program using low-energy structures obtained with the MMFF force field. VolSurf descriptors were calculated from the GRID maps and subsequently analyzed by multivariate statistics. The analysis disclosed the presence of a common motif for possible interactions of the aromadendranes with a putative target receptor. At the same time, a considerable chemical diversity within the library was disclosed, despite a close biosynthetic relationship of its members. The results can be interpreted in terms of evolutionary optimization of structures of secondary metabolites for interaction with macromolecular targets and are of interest in terms of assessment of potential "drug-likeness" of natural products.
Original languageEnglish
JournalJournal of Natural Products
Volume67
Issue number5
Pages (from-to)799-805
Number of pages7
ISSN0163-3864
DOIs
Publication statusPublished - 2004

    Research areas

  • Apocynaceae, Combinatorial Chemistry Techniques, Ghana, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Roots, Sesquiterpenes, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

ID: 38393998