Ligand binding by PDZ domains

Research output: Contribution to journalJournal articleResearchpeer-review

Celestine N. Chi, Anders Bach, Kristian Strømgaard, Stefano Gianni, Per Jemth

The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common protein-protein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.
Original languageEnglish
JournalBioFactors
Volume38
Issue number5
Pages (from-to)338-348 (Review)
Number of pages11
ISSN0951-6433
DOIs
Publication statusPublished - 2012

    Research areas

  • Animals, Binding Sites, Humans, Ligands, Models, Molecular, Nerve Tissue Proteins, Nervous System Diseases, PDZ Domains, Peptidomimetics, Protein Binding, Protein Structure, Secondary, Protein Transport, Signal Transduction

ID: 45807203