MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull

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MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull. / Saaby, Lasse; Rasmussen, Hasse Bonde; Jäger, Anna Katharina.

In: Journal of Ethnopharmacology, Vol. 121, No. 1, 2009, p. 178-181.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Saaby, L, Rasmussen, HB & Jäger, AK 2009, 'MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull', Journal of Ethnopharmacology, vol. 121, no. 1, pp. 178-181. https://doi.org/10.1016/j.jep.2008.10.012

APA

Saaby, L., Rasmussen, H. B., & Jäger, A. K. (2009). MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull. Journal of Ethnopharmacology, 121(1), 178-181. https://doi.org/10.1016/j.jep.2008.10.012

Vancouver

Saaby L, Rasmussen HB, Jäger AK. MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull. Journal of Ethnopharmacology. 2009;121(1):178-181. https://doi.org/10.1016/j.jep.2008.10.012

Author

Saaby, Lasse ; Rasmussen, Hasse Bonde ; Jäger, Anna Katharina. / MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull. In: Journal of Ethnopharmacology. 2009 ; Vol. 121, No. 1. pp. 178-181.

Bibtex

@article{f326fea0db1811dd9473000ea68e967b,
title = "MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull",
abstract = "AIM OF THE STUDY: This study investigated MAO-A inhibitory activity of methanol extract of Calluna vulgaris (L.) Hull., which traditionally has been used as a nerve calming remedy. MATERIALS AND METHODS: A methanolic extract of Calluna vulgaris was partitioned against heptane, ethyl acetate and water. The three fractions were tested in a photometric peroxidase linked MAO-A bioassay. The ethyl acetate phase showed the highest MAO-A inhibitory activity. Quercetin was isolated by VLC through bioassay-guided fractionation and purified by re-crystallisation. The structure was elucidated by LC-MS and (1)H NMR. RESULTS: The IC(50)-value for MAO-A inhibition by quercetin was 18+/-0.2muM in an assay where the IC(50)-value for MAO-A inhibition by clorgylin was 0.2+/-0.02muM. CONCLUSION: The content of quercetin in Calluna vulgaris might explain the reported nerve calming effect of the plant.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Lasse Saaby and Rasmussen, {Hasse Bonde} and J{\"a}ger, {Anna Katharina}",
note = "Keywords: Calluna Vulgaris; Eriaceae; Monoamine oxidase A inhibitor; Quercetin; Traditional medicine",
year = "2009",
doi = "10.1016/j.jep.2008.10.012",
language = "English",
volume = "121",
pages = "178--181",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull

AU - Saaby, Lasse

AU - Rasmussen, Hasse Bonde

AU - Jäger, Anna Katharina

N1 - Keywords: Calluna Vulgaris; Eriaceae; Monoamine oxidase A inhibitor; Quercetin; Traditional medicine

PY - 2009

Y1 - 2009

N2 - AIM OF THE STUDY: This study investigated MAO-A inhibitory activity of methanol extract of Calluna vulgaris (L.) Hull., which traditionally has been used as a nerve calming remedy. MATERIALS AND METHODS: A methanolic extract of Calluna vulgaris was partitioned against heptane, ethyl acetate and water. The three fractions were tested in a photometric peroxidase linked MAO-A bioassay. The ethyl acetate phase showed the highest MAO-A inhibitory activity. Quercetin was isolated by VLC through bioassay-guided fractionation and purified by re-crystallisation. The structure was elucidated by LC-MS and (1)H NMR. RESULTS: The IC(50)-value for MAO-A inhibition by quercetin was 18+/-0.2muM in an assay where the IC(50)-value for MAO-A inhibition by clorgylin was 0.2+/-0.02muM. CONCLUSION: The content of quercetin in Calluna vulgaris might explain the reported nerve calming effect of the plant.

AB - AIM OF THE STUDY: This study investigated MAO-A inhibitory activity of methanol extract of Calluna vulgaris (L.) Hull., which traditionally has been used as a nerve calming remedy. MATERIALS AND METHODS: A methanolic extract of Calluna vulgaris was partitioned against heptane, ethyl acetate and water. The three fractions were tested in a photometric peroxidase linked MAO-A bioassay. The ethyl acetate phase showed the highest MAO-A inhibitory activity. Quercetin was isolated by VLC through bioassay-guided fractionation and purified by re-crystallisation. The structure was elucidated by LC-MS and (1)H NMR. RESULTS: The IC(50)-value for MAO-A inhibition by quercetin was 18+/-0.2muM in an assay where the IC(50)-value for MAO-A inhibition by clorgylin was 0.2+/-0.02muM. CONCLUSION: The content of quercetin in Calluna vulgaris might explain the reported nerve calming effect of the plant.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.jep.2008.10.012

DO - 10.1016/j.jep.2008.10.012

M3 - Journal article

VL - 121

SP - 178

EP - 181

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 1

ER -

ID: 9509860