MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull

Research output: Contribution to journalJournal articleResearchpeer-review

Lasse Saaby, Hasse Bonde Rasmussen, Anna Katharina Jäger

AIM OF THE STUDY: This study investigated MAO-A inhibitory activity of methanol extract of Calluna vulgaris (L.) Hull., which traditionally has been used as a nerve calming remedy. MATERIALS AND METHODS: A methanolic extract of Calluna vulgaris was partitioned against heptane, ethyl acetate and water. The three fractions were tested in a photometric peroxidase linked MAO-A bioassay. The ethyl acetate phase showed the highest MAO-A inhibitory activity. Quercetin was isolated by VLC through bioassay-guided fractionation and purified by re-crystallisation. The structure was elucidated by LC-MS and (1)H NMR. RESULTS: The IC(50)-value for MAO-A inhibition by quercetin was 18+/-0.2muM in an assay where the IC(50)-value for MAO-A inhibition by clorgylin was 0.2+/-0.02muM. CONCLUSION: The content of quercetin in Calluna vulgaris might explain the reported nerve calming effect of the plant.
Original languageEnglish
JournalJournal of Ethnopharmacology
Volume121
Issue number1
Pages (from-to)178-181
ISSN0378-8741
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Calluna Vulgaris; Eriaceae; Monoamine oxidase A inhibitor; Quercetin; Traditional medicine

ID: 9509860