Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

Research output: Contribution to journalJournal article

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Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma. / Ahmadi, Hamid; Lund-Andersen, Henrik; Kolko, Miriam; Bach-Holm, Daniella; Alberti, Mark; Ba-Ali, Shakoor.

In: Acta Ophthalmologica, Vol. 98, No. 1, 2020, p. 65-73.

Research output: Contribution to journalJournal article

Harvard

Ahmadi, H, Lund-Andersen, H, Kolko, M, Bach-Holm, D, Alberti, M & Ba-Ali, S 2020, 'Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma', Acta Ophthalmologica, vol. 98, no. 1, pp. 65-73. https://doi.org/10.1111/aos.14133

APA

Ahmadi, H., Lund-Andersen, H., Kolko, M., Bach-Holm, D., Alberti, M., & Ba-Ali, S. (2020). Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma. Acta Ophthalmologica, 98(1), 65-73. https://doi.org/10.1111/aos.14133

Vancouver

Ahmadi H, Lund-Andersen H, Kolko M, Bach-Holm D, Alberti M, Ba-Ali S. Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma. Acta Ophthalmologica. 2020;98(1):65-73. https://doi.org/10.1111/aos.14133

Author

Ahmadi, Hamid ; Lund-Andersen, Henrik ; Kolko, Miriam ; Bach-Holm, Daniella ; Alberti, Mark ; Ba-Ali, Shakoor. / Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma. In: Acta Ophthalmologica. 2020 ; Vol. 98, No. 1. pp. 65-73.

Bibtex

@article{b593ee7c7ee2428c9b7008d019b2afe7,
title = "Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma",
abstract = "Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) and sleep quality are impaired in patients with primary open-angle glaucoma (POAG). In this study, we investigated whether ipRGCs and sleep quality were also impaired in patients with normal tension glaucoma (NTG). Methods: We performed pupillometry and sleep quality assessment in 15 patients with NTG and 17 healthy age-matched controls. Pupillometry protocol consisted of monocular stimulation with high illuminance (100 lux) red (633 nm, 300 cd/m 2 or 15.23 log quanta/cm 2 /s) and blue light (463 nm, 332 cd/m 2 or 15.27 log quanta/cm 2 /s) and binocular pupil measurements. Prior to light stimulation, patients were dark-adapted for 5 min. The late postillumination pupillary response (PIPR L ate ) to blue light was used as marker of ipRGC activity. Sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: The PIPR L ate to blue light was significantly reduced in patients with NTG compared to healthy subjects (p < 0.001), indicating impairment of the melanopsin-mediated pupillary pathway. There was no significant difference in the response elicited by red light (p = 0.6). Baseline pupil diameter and pupillary constriction amplitude to both red and blue light were reduced in patients with NTG (p < 0.05). The global score in PSQI was not significantly different between healthy controls and patients with NTG, indicating normal sleep quality (p = 0.6). Furthermore, we found no correlation between sleep parameters and pupillary light reflex parameters. Conclusion: Patients with NTG exhibited reduced ipRGC activity compared to healthy subjects, while no differences were observed in sleep quality.",
keywords = "intrinsically photosensitive retinal ganglion cells, normal tension glaucoma, postillumination pupillary response, pupillary light reflex, sleep",
author = "Hamid Ahmadi and Henrik Lund-Andersen and Miriam Kolko and Daniella Bach-Holm and Mark Alberti and Shakoor Ba-Ali",
year = "2020",
doi = "10.1111/aos.14133",
language = "English",
volume = "98",
pages = "65--73",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

AU - Ahmadi, Hamid

AU - Lund-Andersen, Henrik

AU - Kolko, Miriam

AU - Bach-Holm, Daniella

AU - Alberti, Mark

AU - Ba-Ali, Shakoor

PY - 2020

Y1 - 2020

N2 - Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) and sleep quality are impaired in patients with primary open-angle glaucoma (POAG). In this study, we investigated whether ipRGCs and sleep quality were also impaired in patients with normal tension glaucoma (NTG). Methods: We performed pupillometry and sleep quality assessment in 15 patients with NTG and 17 healthy age-matched controls. Pupillometry protocol consisted of monocular stimulation with high illuminance (100 lux) red (633 nm, 300 cd/m 2 or 15.23 log quanta/cm 2 /s) and blue light (463 nm, 332 cd/m 2 or 15.27 log quanta/cm 2 /s) and binocular pupil measurements. Prior to light stimulation, patients were dark-adapted for 5 min. The late postillumination pupillary response (PIPR L ate ) to blue light was used as marker of ipRGC activity. Sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: The PIPR L ate to blue light was significantly reduced in patients with NTG compared to healthy subjects (p < 0.001), indicating impairment of the melanopsin-mediated pupillary pathway. There was no significant difference in the response elicited by red light (p = 0.6). Baseline pupil diameter and pupillary constriction amplitude to both red and blue light were reduced in patients with NTG (p < 0.05). The global score in PSQI was not significantly different between healthy controls and patients with NTG, indicating normal sleep quality (p = 0.6). Furthermore, we found no correlation between sleep parameters and pupillary light reflex parameters. Conclusion: Patients with NTG exhibited reduced ipRGC activity compared to healthy subjects, while no differences were observed in sleep quality.

AB - Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) and sleep quality are impaired in patients with primary open-angle glaucoma (POAG). In this study, we investigated whether ipRGCs and sleep quality were also impaired in patients with normal tension glaucoma (NTG). Methods: We performed pupillometry and sleep quality assessment in 15 patients with NTG and 17 healthy age-matched controls. Pupillometry protocol consisted of monocular stimulation with high illuminance (100 lux) red (633 nm, 300 cd/m 2 or 15.23 log quanta/cm 2 /s) and blue light (463 nm, 332 cd/m 2 or 15.27 log quanta/cm 2 /s) and binocular pupil measurements. Prior to light stimulation, patients were dark-adapted for 5 min. The late postillumination pupillary response (PIPR L ate ) to blue light was used as marker of ipRGC activity. Sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: The PIPR L ate to blue light was significantly reduced in patients with NTG compared to healthy subjects (p < 0.001), indicating impairment of the melanopsin-mediated pupillary pathway. There was no significant difference in the response elicited by red light (p = 0.6). Baseline pupil diameter and pupillary constriction amplitude to both red and blue light were reduced in patients with NTG (p < 0.05). The global score in PSQI was not significantly different between healthy controls and patients with NTG, indicating normal sleep quality (p = 0.6). Furthermore, we found no correlation between sleep parameters and pupillary light reflex parameters. Conclusion: Patients with NTG exhibited reduced ipRGC activity compared to healthy subjects, while no differences were observed in sleep quality.

KW - intrinsically photosensitive retinal ganglion cells

KW - normal tension glaucoma

KW - postillumination pupillary response

KW - pupillary light reflex

KW - sleep

U2 - 10.1111/aos.14133

DO - 10.1111/aos.14133

M3 - Journal article

C2 - 31062491

AN - SCOPUS:85065473305

VL - 98

SP - 65

EP - 73

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 1

ER -

ID: 227582233