Metabolic fate of hallucinogenic NBOMes

Research output: Contribution to journalJournal articleResearchpeer-review

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Metabolic fate of hallucinogenic NBOMes. / Leth-Petersen, Sebastian; Gabel-Jensen, Charlotte; Gillings, Nic; Lehel, Szabolzs; Hansen, Hanne D; Knudsen, Gitte M; Kristensen, Jesper L.

In: Chemical Research in Toxicology, Vol. 29, No. 1, 2016, p. 96–100.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Leth-Petersen, S, Gabel-Jensen, C, Gillings, N, Lehel, S, Hansen, HD, Knudsen, GM & Kristensen, JL 2016, 'Metabolic fate of hallucinogenic NBOMes' Chemical Research in Toxicology, vol. 29, no. 1, pp. 96–100. https://doi.org/10.1021/acs.chemrestox.5b00450

APA

Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M., & Kristensen, J. L. (2016). Metabolic fate of hallucinogenic NBOMes. Chemical Research in Toxicology, 29(1), 96–100. https://doi.org/10.1021/acs.chemrestox.5b00450

Vancouver

Leth-Petersen S, Gabel-Jensen C, Gillings N, Lehel S, Hansen HD, Knudsen GM et al. Metabolic fate of hallucinogenic NBOMes. Chemical Research in Toxicology. 2016;29(1):96–100. https://doi.org/10.1021/acs.chemrestox.5b00450

Author

Leth-Petersen, Sebastian ; Gabel-Jensen, Charlotte ; Gillings, Nic ; Lehel, Szabolzs ; Hansen, Hanne D ; Knudsen, Gitte M ; Kristensen, Jesper L. / Metabolic fate of hallucinogenic NBOMes. In: Chemical Research in Toxicology. 2016 ; Vol. 29, No. 1. pp. 96–100.

Bibtex

@article{21f330e850614a7a97c16bd465b0350d,
title = "Metabolic fate of hallucinogenic NBOMes",
abstract = "2,5-dimethoxy-N-benzylphenethylamines (NBOMes) are very potent 5-HT2AR agonists. Illicit use of these psychedelic compounds has emerged in recent years, and several fatalities have been linked to their recreational use. In its [11C]-labelled form, one NBOMe (25B-NBOMe) was recently developed as a PET-ligand for clinical investigations of the 5HT2AR ([11C]Cimbi-36). Herein, we have identified the phase I and phase II metabolites of 25B-NBOMe in pigs as well as in humans. We find that the primary route of metabolism is 5'-demethylation, followed by conjugation to glucuronic acid. [11C]-labelling of 25B-NBOMe in three different positions followed by in vivo evaluation in pigs and in humans corroborated these findings.",
author = "Sebastian Leth-Petersen and Charlotte Gabel-Jensen and Nic Gillings and Szabolzs Lehel and Hansen, {Hanne D} and Knudsen, {Gitte M} and Kristensen, {Jesper L}",
year = "2016",
doi = "10.1021/acs.chemrestox.5b00450",
language = "English",
volume = "29",
pages = "96–100",
journal = "Chemical Research in Toxicology",
issn = "0893-228X",
publisher = "American Chemical Society",
number = "1",

}

RIS

TY - JOUR

T1 - Metabolic fate of hallucinogenic NBOMes

AU - Leth-Petersen, Sebastian

AU - Gabel-Jensen, Charlotte

AU - Gillings, Nic

AU - Lehel, Szabolzs

AU - Hansen, Hanne D

AU - Knudsen, Gitte M

AU - Kristensen, Jesper L

PY - 2016

Y1 - 2016

N2 - 2,5-dimethoxy-N-benzylphenethylamines (NBOMes) are very potent 5-HT2AR agonists. Illicit use of these psychedelic compounds has emerged in recent years, and several fatalities have been linked to their recreational use. In its [11C]-labelled form, one NBOMe (25B-NBOMe) was recently developed as a PET-ligand for clinical investigations of the 5HT2AR ([11C]Cimbi-36). Herein, we have identified the phase I and phase II metabolites of 25B-NBOMe in pigs as well as in humans. We find that the primary route of metabolism is 5'-demethylation, followed by conjugation to glucuronic acid. [11C]-labelling of 25B-NBOMe in three different positions followed by in vivo evaluation in pigs and in humans corroborated these findings.

AB - 2,5-dimethoxy-N-benzylphenethylamines (NBOMes) are very potent 5-HT2AR agonists. Illicit use of these psychedelic compounds has emerged in recent years, and several fatalities have been linked to their recreational use. In its [11C]-labelled form, one NBOMe (25B-NBOMe) was recently developed as a PET-ligand for clinical investigations of the 5HT2AR ([11C]Cimbi-36). Herein, we have identified the phase I and phase II metabolites of 25B-NBOMe in pigs as well as in humans. We find that the primary route of metabolism is 5'-demethylation, followed by conjugation to glucuronic acid. [11C]-labelling of 25B-NBOMe in three different positions followed by in vivo evaluation in pigs and in humans corroborated these findings.

U2 - 10.1021/acs.chemrestox.5b00450

DO - 10.1021/acs.chemrestox.5b00450

M3 - Journal article

VL - 29

SP - 96

EP - 100

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

SN - 0893-228X

IS - 1

ER -

ID: 151839371