Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

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Ahmed R Hassan, Salah M El-Kousy, Sayed A El-Toumy, Karla Frydenvang, Truong Thanh Tung, Jesper Olsen, John Nielsen, Søren Brøgger Christensen

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

Original languageEnglish
JournalJournal of Natural Products
Volume80
Pages (from-to)2830-2834
Number of pages5
ISSN0163-3864
DOIs
Publication statusPublished - 27 Oct 2017

    Research areas

  • Journal Article

ID: 183701308