Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo

Research output: Contribution to journalJournal articleResearchpeer-review

Marta Grodzik, Ewa Sawosz, Mateusz Wierzbicki, Piotr Orlowski, Anna Malgorzata Hotowy, Tomasz Niemiec, Maciej Szmidt, Katarzyna Mitura, André Chwalibog

The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chrioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.
Original languageEnglish
JournalInternational Journal of Nanomedicine (Online)
Volume6
Pages (from-to)3041-3048
Number of pages8
ISSN1176-9114
DOIs
Publication statusPublished - 2011

ID: 35371504