Near-infrared spectroscopy for cocrystal screening: a comparative study with Raman spectroscopy

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Near-infrared spectroscopy for cocrystal screening : a comparative study with Raman spectroscopy. / Allesø, Morten; Velaga, Sitaram; Alhalaweh, Amjad; Cornett, Claus; Rasmussen, Morten Arendt; Van Der Berg, Franciscus Winfried J; de Diego, Heidi Lopez; Rantanen, Jukka.

In: Analytical Chemistry, Vol. 80, No. 20, 2008, p. 7755-7764.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Allesø, M, Velaga, S, Alhalaweh, A, Cornett, C, Rasmussen, MA, Van Der Berg, FWJ, de Diego, HL & Rantanen, J 2008, 'Near-infrared spectroscopy for cocrystal screening: a comparative study with Raman spectroscopy', Analytical Chemistry, vol. 80, no. 20, pp. 7755-7764. https://doi.org/10.1021/ac8011329

APA

Allesø, M., Velaga, S., Alhalaweh, A., Cornett, C., Rasmussen, M. A., Van Der Berg, F. W. J., ... Rantanen, J. (2008). Near-infrared spectroscopy for cocrystal screening: a comparative study with Raman spectroscopy. Analytical Chemistry, 80(20), 7755-7764. https://doi.org/10.1021/ac8011329

Vancouver

Allesø M, Velaga S, Alhalaweh A, Cornett C, Rasmussen MA, Van Der Berg FWJ et al. Near-infrared spectroscopy for cocrystal screening: a comparative study with Raman spectroscopy. Analytical Chemistry. 2008;80(20):7755-7764. https://doi.org/10.1021/ac8011329

Author

Allesø, Morten ; Velaga, Sitaram ; Alhalaweh, Amjad ; Cornett, Claus ; Rasmussen, Morten Arendt ; Van Der Berg, Franciscus Winfried J ; de Diego, Heidi Lopez ; Rantanen, Jukka. / Near-infrared spectroscopy for cocrystal screening : a comparative study with Raman spectroscopy. In: Analytical Chemistry. 2008 ; Vol. 80, No. 20. pp. 7755-7764.

Bibtex

@article{28ef12d0c69b11dd9473000ea68e967b,
title = "Near-infrared spectroscopy for cocrystal screening: a comparative study with Raman spectroscopy",
abstract = "Near-infrared (NIR) spectroscopy is a well-established technique for solid-state analysis, providing fast, noninvasive measurements. The use of NIR spectroscopy for polymorph screening and the associated advantages have recently been demonstrated. The objective of this work was to evaluate the analytical potential of NIR spectroscopy for cocrystal screening using Raman spectroscopy as a comparative method. Indomethacin was used as the parent molecule, while saccharin and l-aspartic acid were chosen as guest molecules. Molar ratios of 1:1 for each system were subjected to two types of preparative methods. In the case of saccharin, liquid-assisted cogrinding as well as cocrystallization from solution resulted in a stable 1:1 cocrystalline phase termed IND-SAC cocrystal. For l-aspartic acid, the solution-based method resulted in a polymorphic transition of indomethacin into the metastable alpha form retained in a physical mixture with the guest molecule, while liquid-assisted cogrinding did not induce any changes in the crystal lattice. The good chemical peak selectivity of Raman spectroscopy allowed a straightforward interpretation of sample data by analyzing peak positions and comparing to those of pure references. In addition, Raman spectroscopy provided additional information on the crystal structure of the IND-SAC cocrystal. The broad spectral line shapes of NIR spectra make visual interpretation of the spectra difficult, and consequently, multivariate modeling by principal component analysis (PCA) was applied. Successful use of NIR/PCA was possible only through the inclusion of a set of reference mixtures of parent and guest molecules representing possible solid-state outcomes from the cocrystal screening. The practical hurdle related to the need for reference mixtures seems to restrict the applicability of NIR spectroscopy in cocrystal screening.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Morten Alles{\o} and Sitaram Velaga and Amjad Alhalaweh and Claus Cornett and Rasmussen, {Morten Arendt} and {Van Der Berg}, {Franciscus Winfried J} and {de Diego}, {Heidi Lopez} and Jukka Rantanen",
year = "2008",
doi = "10.1021/ac8011329",
language = "English",
volume = "80",
pages = "7755--7764",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "20",

}

RIS

TY - JOUR

T1 - Near-infrared spectroscopy for cocrystal screening

T2 - a comparative study with Raman spectroscopy

AU - Allesø, Morten

AU - Velaga, Sitaram

AU - Alhalaweh, Amjad

AU - Cornett, Claus

AU - Rasmussen, Morten Arendt

AU - Van Der Berg, Franciscus Winfried J

AU - de Diego, Heidi Lopez

AU - Rantanen, Jukka

PY - 2008

Y1 - 2008

N2 - Near-infrared (NIR) spectroscopy is a well-established technique for solid-state analysis, providing fast, noninvasive measurements. The use of NIR spectroscopy for polymorph screening and the associated advantages have recently been demonstrated. The objective of this work was to evaluate the analytical potential of NIR spectroscopy for cocrystal screening using Raman spectroscopy as a comparative method. Indomethacin was used as the parent molecule, while saccharin and l-aspartic acid were chosen as guest molecules. Molar ratios of 1:1 for each system were subjected to two types of preparative methods. In the case of saccharin, liquid-assisted cogrinding as well as cocrystallization from solution resulted in a stable 1:1 cocrystalline phase termed IND-SAC cocrystal. For l-aspartic acid, the solution-based method resulted in a polymorphic transition of indomethacin into the metastable alpha form retained in a physical mixture with the guest molecule, while liquid-assisted cogrinding did not induce any changes in the crystal lattice. The good chemical peak selectivity of Raman spectroscopy allowed a straightforward interpretation of sample data by analyzing peak positions and comparing to those of pure references. In addition, Raman spectroscopy provided additional information on the crystal structure of the IND-SAC cocrystal. The broad spectral line shapes of NIR spectra make visual interpretation of the spectra difficult, and consequently, multivariate modeling by principal component analysis (PCA) was applied. Successful use of NIR/PCA was possible only through the inclusion of a set of reference mixtures of parent and guest molecules representing possible solid-state outcomes from the cocrystal screening. The practical hurdle related to the need for reference mixtures seems to restrict the applicability of NIR spectroscopy in cocrystal screening.

AB - Near-infrared (NIR) spectroscopy is a well-established technique for solid-state analysis, providing fast, noninvasive measurements. The use of NIR spectroscopy for polymorph screening and the associated advantages have recently been demonstrated. The objective of this work was to evaluate the analytical potential of NIR spectroscopy for cocrystal screening using Raman spectroscopy as a comparative method. Indomethacin was used as the parent molecule, while saccharin and l-aspartic acid were chosen as guest molecules. Molar ratios of 1:1 for each system were subjected to two types of preparative methods. In the case of saccharin, liquid-assisted cogrinding as well as cocrystallization from solution resulted in a stable 1:1 cocrystalline phase termed IND-SAC cocrystal. For l-aspartic acid, the solution-based method resulted in a polymorphic transition of indomethacin into the metastable alpha form retained in a physical mixture with the guest molecule, while liquid-assisted cogrinding did not induce any changes in the crystal lattice. The good chemical peak selectivity of Raman spectroscopy allowed a straightforward interpretation of sample data by analyzing peak positions and comparing to those of pure references. In addition, Raman spectroscopy provided additional information on the crystal structure of the IND-SAC cocrystal. The broad spectral line shapes of NIR spectra make visual interpretation of the spectra difficult, and consequently, multivariate modeling by principal component analysis (PCA) was applied. Successful use of NIR/PCA was possible only through the inclusion of a set of reference mixtures of parent and guest molecules representing possible solid-state outcomes from the cocrystal screening. The practical hurdle related to the need for reference mixtures seems to restrict the applicability of NIR spectroscopy in cocrystal screening.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/ac8011329

DO - 10.1021/ac8011329

M3 - Journal article

VL - 80

SP - 7755

EP - 7764

JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

IS - 20

ER -

ID: 9040414