No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

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Petrine Wellendorph, Lars Dan Johansen, Anders Asbjørn Jensen, Emilio Casanova, Martin Gassmann, Pierre Deprez, Philippe Clément-Lacroix, Bernhard Bettler, Hans Bräuner-Osborne

GPRC6A is a seven transmembrane receptor mediating signaling by a wide range of L-alpha-amino-acids, a signaling augmented by the divalent cations Ca2+ and Mg2+. GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the closely related calcium-sensing receptor, GPRC6A has been proposed to function as a metabolic sensor of Ca2+ and amino acids in bone and other tissues. In the present study, we have generated the first GPRC6A knockout mice and studied their phenotype with particular focus on bone homeostasis. The generated GPRC6A knockout mice are viable and fertile, develop normally and exhibit no significant differences in body weight compared to wild type littermates. Assessment of bone mineral density, histomorphometry and bone metabolism demonstrated no significant differences between 13-week-old knockout and wild type mice. In conclusion, our data do not support a role for GPRC6A in normal bone physiology.
Original languageEnglish
JournalJournal of Molecular Endocrinology
Volume42
Issue number3
Pages (from-to)215-223
ISSN0952-5041
DOIs
Publication statusPublished - 2009

ID: 10248157