Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium

Research output: Contribution to journalJournal articleResearchpeer-review

Jesper Tjørnhøj Rosenkrantz, Henk Aarts, Tjakko Abee, Matthew D. Rolfe, Gitte Maegaard Knudsen, Maj-Britt Nielsen, Line Elnif Thomsen, Marcel H. Zwietering, John Elmerdahl Olsen, Carmen Pin

Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.
Original languageEnglish
Article number294
JournalB M C Microbiology
Volume13
Number of pages16
ISSN1471-2180
DOIs
Publication statusPublished - 2013

ID: 92299428