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Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

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Mohamed A Shehata, Anne Cathrine Nøhr Jensen, Delphine Lissa, Christoph Bisig, Vignir Isberg, Kirsten B Andersen, Kasper Harpsøe, Fredrik Björkling, Hans Bräuner-Osborne, David E Gloriam

GPR139 is an orphan class A G protein-coupled receptor found mainly in the central nervous system. It has its highest expression levels in the hypothalamus and striatum, regions regulating metabolism and locomotion, respectively, and has therefore been suggested as a potential target for obesity and Parkinson's disease. The two aromatic amino acids L-Trp and L-Phe have been proposed as putative endogenous agonists, and three structurally related benzohydrazide, glycine benzamide, and benzotriazine surrogate agonist series have been published. Herein, we assayed 158 new analogues selected from a pharmacophore model, and identified 12 new GPR139 agonists, containing previously untested bioisosteres. Furthermore, we present the first combined structure-activity relationships, and a refined pharmacophore model to serve as a rationale for future ligand identification and optimization.

Original languageEnglish
Article number36681
JournalScientific Reports
Volume6
Pages (from-to)1-13
Number of pages13
ISSN2045-2322
DOIs
StatePublished - 10 Nov 2016

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