Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages
Research output: Contribution to journal › Journal article › Research › peer-review
The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.
|Journal||European Journal of Organic Chemistry|
|Number of pages||6|
|Publication status||Published - 18 Jan 2017|
- Comparative studies, Isotopic labeling, Nucleophilic substitution, Spiro compounds, Ylides