Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

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Michael Tvilling Madsen, Bülent Kücükakin, Jens Lykkesfeldt, Jacob Rosenberg, Ismail Gögenur

Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P
Original languageEnglish
JournalSurgical Laparoscopy, Endoscopy and Percutaneous Techniques
Volume22
Issue number3
Pages (from-to)215-219
Number of pages5
ISSN1530-4515
DOIs
Publication statusPublished - 2012

ID: 40191970