Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones

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Quaternary centers can be created asymmetrically in high enantiomeric excess by the proper choice of ligand and metal cation in the Pd-catalyzed asymmetric allylic alkylation of a-aryl ketones. A broad range of ketone enolates can be tolerated in the reaction, as illustrated by the synthesis of conformationally constrained ß-tetralone in 96% ee (see scheme, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
Original languageEnglish
JournalAngewandte Chemie International Edition
Issue number18
Pages (from-to)3492-3495
Number of pages4
Publication statusPublished - 16 Sep 2002
Externally publishedYes

ID: 45438013