Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

Research output: Contribution to journalJournal articleResearchpeer-review

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Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes. / Andersen, Valdemar Lykke; Herth, Matthias Manfred; Lehel, Szabolcs; Knudsen, Gitte Moos; Kristensen, Jesper Langgaard.

In: Tetrahedron Letters, Vol. 54, No. 3, 2013, p. 213-216.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Andersen, VL, Herth, MM, Lehel, S, Knudsen, GM & Kristensen, JL 2013, 'Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes', Tetrahedron Letters, vol. 54, no. 3, pp. 213-216. https://doi.org/10.1016/j.tetlet.2012.11.001

APA

Andersen, V. L., Herth, M. M., Lehel, S., Knudsen, G. M., & Kristensen, J. L. (2013). Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes. Tetrahedron Letters, 54(3), 213-216. https://doi.org/10.1016/j.tetlet.2012.11.001

Vancouver

Andersen VL, Herth MM, Lehel S, Knudsen GM, Kristensen JL. Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes. Tetrahedron Letters. 2013;54(3):213-216. https://doi.org/10.1016/j.tetlet.2012.11.001

Author

Andersen, Valdemar Lykke ; Herth, Matthias Manfred ; Lehel, Szabolcs ; Knudsen, Gitte Moos ; Kristensen, Jesper Langgaard. / Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes. In: Tetrahedron Letters. 2013 ; Vol. 54, No. 3. pp. 213-216.

Bibtex

@article{861cc7d1c297476c9ed23288f5fa45b4,
title = "Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes",
abstract = "Cross-couplings are an alternative to conventional 11C-methylations which are generally employed in PET tracer synthesis. Therefore, we set out to develop a general procedure for the synthesis of para-11CH3 labeled aromatic amines from the corresponding para-aminoarylboronic esters in the presence of free amines. Aryl boronic esters containing primary, secondary, and tertiary amines were successfully converted into corresponding labeled methyl derivatives in suf¿cient radiochemical yield to apply thismethod for tracer development. This procedure was applied to the labeling of CIMBI-712, a promisingcandidate for the in vivo imaging of the 5-HT 7 receptor in the CNS",
author = "Andersen, {Valdemar Lykke} and Herth, {Matthias Manfred} and Szabolcs Lehel and Knudsen, {Gitte Moos} and Kristensen, {Jesper Langgaard}",
year = "2013",
doi = "10.1016/j.tetlet.2012.11.001",
language = "English",
volume = "54",
pages = "213--216",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Pergamon Press",
number = "3",

}

RIS

TY - JOUR

T1 - Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

AU - Andersen, Valdemar Lykke

AU - Herth, Matthias Manfred

AU - Lehel, Szabolcs

AU - Knudsen, Gitte Moos

AU - Kristensen, Jesper Langgaard

PY - 2013

Y1 - 2013

N2 - Cross-couplings are an alternative to conventional 11C-methylations which are generally employed in PET tracer synthesis. Therefore, we set out to develop a general procedure for the synthesis of para-11CH3 labeled aromatic amines from the corresponding para-aminoarylboronic esters in the presence of free amines. Aryl boronic esters containing primary, secondary, and tertiary amines were successfully converted into corresponding labeled methyl derivatives in suf¿cient radiochemical yield to apply thismethod for tracer development. This procedure was applied to the labeling of CIMBI-712, a promisingcandidate for the in vivo imaging of the 5-HT 7 receptor in the CNS

AB - Cross-couplings are an alternative to conventional 11C-methylations which are generally employed in PET tracer synthesis. Therefore, we set out to develop a general procedure for the synthesis of para-11CH3 labeled aromatic amines from the corresponding para-aminoarylboronic esters in the presence of free amines. Aryl boronic esters containing primary, secondary, and tertiary amines were successfully converted into corresponding labeled methyl derivatives in suf¿cient radiochemical yield to apply thismethod for tracer development. This procedure was applied to the labeling of CIMBI-712, a promisingcandidate for the in vivo imaging of the 5-HT 7 receptor in the CNS

U2 - 10.1016/j.tetlet.2012.11.001

DO - 10.1016/j.tetlet.2012.11.001

M3 - Journal article

VL - 54

SP - 213

EP - 216

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 3

ER -

ID: 43227214