Partial agonists and subunit selectivity at NMDA receptors

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Partial agonists and subunit selectivity at NMDA receptors. / Risgaard, Rune; Hansen, Kasper Bø; Clausen, Rasmus Prætorius.

In: Chemistry: A European Journal, Vol. 16, No. 47, 17.12.2010, p. 13910-13918.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Risgaard, R, Hansen, KB & Clausen, RP 2010, 'Partial agonists and subunit selectivity at NMDA receptors', Chemistry: A European Journal, vol. 16, no. 47, pp. 13910-13918. https://doi.org/10.1002/chem.201001366

APA

Risgaard, R., Hansen, K. B., & Clausen, R. P. (2010). Partial agonists and subunit selectivity at NMDA receptors. Chemistry: A European Journal, 16(47), 13910-13918. https://doi.org/10.1002/chem.201001366

Vancouver

Risgaard R, Hansen KB, Clausen RP. Partial agonists and subunit selectivity at NMDA receptors. Chemistry: A European Journal. 2010 Dec 17;16(47):13910-13918. https://doi.org/10.1002/chem.201001366

Author

Risgaard, Rune ; Hansen, Kasper Bø ; Clausen, Rasmus Prætorius. / Partial agonists and subunit selectivity at NMDA receptors. In: Chemistry: A European Journal. 2010 ; Vol. 16, No. 47. pp. 13910-13918.

Bibtex

@article{5b707efd038a47829ffb39207c9abeb1,
title = "Partial agonists and subunit selectivity at NMDA receptors",
abstract = "Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Rune Risgaard and Hansen, {Kasper B{\o}} and Clausen, {Rasmus Pr{\ae}torius}",
note = "Keywords: agonists, glutamate, ligand design, receptors, subunit selectivity",
year = "2010",
month = "12",
day = "17",
doi = "10.1002/chem.201001366",
language = "English",
volume = "16",
pages = "13910--13918",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "47",

}

RIS

TY - JOUR

T1 - Partial agonists and subunit selectivity at NMDA receptors

AU - Risgaard, Rune

AU - Hansen, Kasper Bø

AU - Clausen, Rasmus Prætorius

N1 - Keywords: agonists, glutamate, ligand design, receptors, subunit selectivity

PY - 2010/12/17

Y1 - 2010/12/17

N2 - Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.

AB - Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/chem.201001366

DO - 10.1002/chem.201001366

M3 - Review

C2 - 20945316

VL - 16

SP - 13910

EP - 13918

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

IS - 47

ER -

ID: 33701222