Partial agonists and subunit selectivity at NMDA receptors
Research output: Contribution to journal › Review › Research › peer-review
Rune Risgaard, Kasper Bø Hansen, Rasmus Prætorius Clausen
Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
|Journal||Chemistry: A European Journal|
|Publication status||Published - 17 Dec 2010|
- Former Faculty of Pharmaceutical Sciences