α-Peptide/ß-Peptoid Chimeras
Research output: Contribution to journal › Journal article › Research › peer-review
Christian Adam Olsen, Gitte Bonke, Line Vedel, Anne Adsersen, Matthias Witt, Henrik Franzyk, Jerzy W. Jaroszewski
We describe the synthesis and characterization of the first generation of oligomers consisting of alternating repeats of a-amino acids and chiral N-alkyl-ß-alanine (ß-peptoid) residues. These chimeras are stable toward proteolysis, non-hemolytic, and possess antibacterial activity comparable to well-known antimicrobial agents. Moreover, the chimeras exhibit length-dependent, concentration-dependent, solvent-dependent, and ion-strength-dependent ellipticity, indicating the presence of a secondary structure in solution. Thus, a-peptide/ß-peptoid oligomers represent a promising novel peptidomimetic backbone construct for biologically active ligands.
Original language | English |
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Journal | Organic Letters |
Volume | 9 |
Issue number | 8 |
Pages (from-to) | 1549–1552 |
Number of pages | 4 |
ISSN | 1523-7060 |
DOIs | |
Publication status | Published - 2007 |
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 2432955