Preparation of a tritiated ginkgolide

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Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Issue number22
Pages (from-to)5673-5675
Number of pages3
Publication statusPublished - 15 Nov 2004

    Research areas

  • Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Molecular Conformation, Tritium

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