PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

Research output: PatentResearch

Claus Selch Larsen (Inventor), Susan Weng Larsen (Inventor), Mette Agergaard Thing (Inventor), Jesper Langgaard Kristensen (Inventor), HENRIK JENSEN, (Inventor), JESPER OESTERGAARD, (Inventor)

The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.

Original languageEnglish
IPCC07D 487/ 04 A I
Patent numberWO2013064153
CountryDenmark
Priority date31/10/2011
Priority numberDK20110070591
Publication statusPublished - 10 May 2013

ID: 171123843