Quality of life in diffuse large B-cell lymphoma patients treated with dose-dense chemotherapy is only affected temporarily

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D Tholstrup, Peter Brown, Jesper Jurlander, PB Jeppesen, Mogens Grønvold

R)-CHOP-14 has substantially improved outcome in DLBCL, but may have increased morbidity and reduced quality of life (QoL). Our aim was to evaluate QoL during (R)-CHOP-14-based chemotherapy. Twenty-six patients participated (small single-center study). EORTC QLQ-C30 was completed pre-treatment, mid-treatment, 14 days post-treatment, and 3 months post-treatment. Scores were compared to a reference population, and analyzed separately. Pre-treatment, global health status (p¿=¿0.004), physical functioning (p¿=¿0.036), role functioning (p¿=¿0.017), and emotional functioning (p¿=¿0.040) were reduced, and fatigue (p¿=¿0.009) and appetite loss (p¿=¿0.007) increased compared to the reference population. During treatment, physical functioning and role functioning decreased significantly, whereas emotional functioning, fatigue, and diarrhea increased. Three months post-treatment, scores were generally equivalent to those of the reference population, and lower for nausea/vomiting (p¿<¿0.001) and constipation (p¿<¿0.001). Disease-related symptoms were frequent in high-risk DLBCL. Treatment-related symptoms were normalized 3 months post-treatment. In conclusion, QoL is only temporarily affected during (R)-CHOP-14-based chemotherapy, and the treatment regimen is therefore feasible.


Original languageEnglish
JournalLeukemia and Lymphoma
Volume52
Issue number3
Pages (from-to)400-408
ISSN1042-8194
DOIs
Publication statusPublished - 2011

ID: 33172389