Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

Research output: Contribution to journalJournal articleResearchpeer-review

Anders Ettrup, Martin Hansen, Martin A Santini, James Stephen Paine, Nic Gillings, Mikael Palner, Szabolcs Lehel, Matthias Manfred Herth, Jacob Madsen, Jesper Langgaard Kristensen, Mikael Begtrup, Gitte Moos Knudsen

Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [(11)C]Cimbi-5 in different ways. Here, we present the in vivo validation of nine novel 5-HT(2A) receptor agonist PET tracers in the pig brain.
Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number4
Pages (from-to)681-693
Publication statusPublished - 1 Apr 2011

ID: 33532649