Rapid functional upregulation of vasocontractile endothelin ETB receptors in rat coronary arteries

Research output: Contribution to journalJournal articleResearchpeer-review

Gry Freja Skovsted, Anne Fog Pedersen, Rikke Larsen, Majid Sheykhzade, Lars Edvinsson

Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.
Original languageEnglish
JournalLife Sciences
Volume91
Issue number13-14
Pages (from-to)593-9
Number of pages7
ISSN2042-4329
DOIs
Publication statusPublished - 2012

ID: 40968474