Role of KATP channels in the regulation of rat dura and pia artery diameter

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The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.
Original languageEnglish
Issue number4
Pages (from-to)249-260
Number of pages12
Publication statusPublished - 2005

    Research areas

  • Former LIFE faculty - Dural and pial arteries, glibenclamide, KATP channels, levcromakalim, pinacidil

ID: 7998707