Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

Research output: Contribution to journalJournal articleResearchpeer-review

Juan J Rubal, Francisco M Guerra, F Javier Moreno-Dorado, Zacarías D Jorge, Guillermo M Massanet, Helmer Søhoel, Ulla W Smitt, Karla Andrea Frydenvang, S Brøgger Christensen, Charlotte Nielsen, Margit Eriksson

Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.
Original languageEnglish
JournalJournal of Natural Products
Volume69
Issue number11
Pages (from-to)1566-71
Number of pages6
ISSN0163-3864
DOIs
Publication statusPublished - 2006

    Research areas

  • Crystallography, X-Ray, Molecular Conformation, Molecular Structure, Plant Roots, Plants, Medicinal, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sesquiterpenes, Spain, Thapsia

ID: 40370954