Structural basis of cell-cell adhesion by NCAM
Research output: Contribution to journal › Journal article › Research › peer-review
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
|Journal||Nature Structural and Molecular Biology|
|Number of pages||5|
|Publication status||Published - 2000|
- Amino Acid Sequence, Animals, Binding Sites, Calcium, Cell Adhesion, Crystallography, X-Ray, Dimerization, Heparin, Hydrogen Bonding, Immunoglobulins, Models, Molecular, Molecular Sequence Data, Neural Cell Adhesion Molecules, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Rats, Sequence Alignment, Structure-Activity Relationship