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Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. / Larsen, Morten; Hansen, Cecilie Hurup; Rasmussen, Tobias B.; Styrishave, Bjarne; Olsen, Lars; Jørgensen, Flemming Steen.

In: Chemical Communications, Vol. 53, No. 3118, 3118, 28.02.2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Larsen, M, Hansen, CH, Rasmussen, TB, Styrishave, B, Olsen, L & Jørgensen, FS 2017, 'Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors' Chemical Communications, vol. 53, no. 3118, 3118. https://doi.org/10.1039/C6CC08680B

APA

Larsen, M., Hansen, C. H., Rasmussen, T. B., Styrishave, B., Olsen, L., & Jørgensen, F. S. (2017). Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. Chemical Communications, 53(3118), [3118]. https://doi.org/10.1039/C6CC08680B

Vancouver

Larsen M, Hansen CH, Rasmussen TB, Styrishave B, Olsen L, Jørgensen FS. Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. Chemical Communications. 2017 Feb 28;53(3118). 3118. https://doi.org/10.1039/C6CC08680B

Author

Larsen, Morten ; Hansen, Cecilie Hurup ; Rasmussen, Tobias B. ; Styrishave, Bjarne ; Olsen, Lars ; Jørgensen, Flemming Steen. / Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. In: Chemical Communications. 2017 ; Vol. 53, No. 3118.

Bibtex

@article{ad5f931a62fe444692aab7b74aaa24da,
title = "Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors",
abstract = "Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.",
author = "Morten Larsen and Hansen, {Cecilie Hurup} and Rasmussen, {Tobias B.} and Bjarne Styrishave and Lars Olsen and J{\o}rgensen, {Flemming Steen}",
year = "2017",
month = "2",
day = "28",
doi = "10.1039/C6CC08680B",
language = "English",
volume = "53",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "3118",

}

RIS

TY - JOUR

T1 - Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors

AU - Larsen, Morten

AU - Hansen, Cecilie Hurup

AU - Rasmussen, Tobias B.

AU - Styrishave, Bjarne

AU - Olsen, Lars

AU - Jørgensen, Flemming Steen

PY - 2017/2/28

Y1 - 2017/2/28

N2 - Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.

AB - Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.

U2 - 10.1039/C6CC08680B

DO - 10.1039/C6CC08680B

M3 - Journal article

VL - 53

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 3118

M1 - 3118

ER -

ID: 174130515