Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors
Research output: Contribution to journal › Journal article › Research › peer-review
Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.
|Number of pages||4|
|Publication status||Published - 28 Feb 2017|