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Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors

Research output: Contribution to journalJournal articleResearchpeer-review

Morten Larsen, Cecilie Hurup Hansen, Tobias B. Rasmussen, Bjarne Styrishave, Lars Olsen, Flemming Steen Jørgensen

Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.
Original languageEnglish
Article number3118
JournalChemical Communications
Volume53
Issue number3118
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 28 Feb 2017

ID: 174130515