Syncytin is involved in breast cancer-endothelial cell fusions

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Bolette Bjerregaard, S. Holck, I.J. Christensen, Lars-Inge Larsson

Cancer cells can fuse spontaneously with normal host cells, including endothelial cells, and such fusions may strongly modulate the biological behaviour of tumors. However, the underlying mechanisms are unknown. We now show that human breast cancer cell lines and 63 out of 165 (38%) breast cancer specimens express syncytin, an endogenous retroviral envelope protein, previously implicated in fusions between placental trophoblast cells. Additionally, endothelial and cancer cells are shown to express ASCT-2, a receptor for syncytin. Syncytin antisense treatment decreases syncytin expression and inhibits fusions between breast cancer cells and endothelial cells. Moreover, a syncytin inhibitory peptide also inhibits fusions between cancer and endothelial cells. These results are the first to show that syncytin is expressed by human cancer cells and is involved in cancer-endothelial cell fusions.
Original languageEnglish
JournalCellular and Molecular Life Sciences
Volume63
Issue number16
Pages (from-to)1906-1911
Number of pages6
ISSN1420-682X
DOIs
Publication statusPublished - 2006

    Research areas

  • LIFE - Syncytin, breast cancer, endothelial cell, fusion, ASCT-2

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