Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures

Research output: Contribution to journalJournal articleResearchpeer-review

M Kolko, M A DeCoster, E B de Turco, N G Bazan, Miriam Kolko

Secretory and cytosolic phospholipases A2 (sPLA2 and cPLA2) may contribute to the release of arachidonic acid and other bioactive lipids, which are modulators of synaptic function. In primary cortical neuron cultures, neurotoxic cell death and [3H]arachidonate metabolism was studied after adding glutamate and sPLA2 from bee venom. sPLA2, at concentrations eliciting low neurotoxicity (

Original languageEnglish
JournalThe Journal of Biological Chemistry
Volume271
Issue number51
Pages (from-to)32722-8
Number of pages7
ISSN0021-9258
Publication statusPublished - 20 Dec 1996

    Research areas

  • Animals, Arachidonic Acid, Bee Venoms, Cell Death, Cells, Cultured, Cerebral Cortex, Dizocilpine Maleate, Drug Synergism, Glutamates, Neurons, Neurotoxins, Phospholipases A, Phospholipases A2, Phospholipids, Rats

ID: 128615130