Synthesis and application of a new fluorous-tagged ammonia equivalent
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A novel fluorous-tagged ammonia equivalent has been developed. It is based on a nitrogen-oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluorous N--O linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional dyspepsia. Itopride was synthesized with the aid of fluorous purification methods and the product was isolated in good overall yield, with high purity.
|Journal||Chemistry: A European Journal|
|Publication status||Published - 2010|
Keywords: ammonia equivalents; cleavage reactions; flourous synthesis; itopride; molybdenum
- Former Faculty of Pharmaceutical Sciences