Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug
Research output: Contribution to journal › Journal article › Research › peer-review
Dorthe Mondrup Skytte, Karla Andrea Frydenvang, Liselotte Hansen, Peter G Nielsen, Jerzy W Jaroszewski
8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.
|Journal||Journal of Natural Products|
|Publication status||Published - 18 Feb 2010|
- Former Faculty of Pharmaceutical Sciences