Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues

Research output: Contribution to journalJournal articleResearchpeer-review

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Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. / Valgeirsson, Jon; Christensen, Jeppe K; Kristensen, Anders S; Pickering, Darryl S; Nielsen, Birgitte; Fischer, Christina; Bräuner-Osborne, Hans; Nielsen, Elsebet Ø; Krogsgaard-Larsen, Povl; Madsen, Ulf.

In: Bioorganic & Medicinal Chemistry, Vol. 11, No. 20, 2003, p. 4341-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Valgeirsson, J, Christensen, JK, Kristensen, AS, Pickering, DS, Nielsen, B, Fischer, C, Bräuner-Osborne, H, Nielsen, EØ, Krogsgaard-Larsen, P & Madsen, U 2003, 'Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues', Bioorganic & Medicinal Chemistry, vol. 11, no. 20, pp. 4341-9.

APA

Valgeirsson, J., Christensen, J. K., Kristensen, A. S., Pickering, D. S., Nielsen, B., Fischer, C., ... Madsen, U. (2003). Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. Bioorganic & Medicinal Chemistry, 11(20), 4341-9.

Vancouver

Valgeirsson J, Christensen JK, Kristensen AS, Pickering DS, Nielsen B, Fischer C et al. Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. Bioorganic & Medicinal Chemistry. 2003;11(20):4341-9.

Author

Valgeirsson, Jon ; Christensen, Jeppe K ; Kristensen, Anders S ; Pickering, Darryl S ; Nielsen, Birgitte ; Fischer, Christina ; Bräuner-Osborne, Hans ; Nielsen, Elsebet Ø ; Krogsgaard-Larsen, Povl ; Madsen, Ulf. / Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. In: Bioorganic & Medicinal Chemistry. 2003 ; Vol. 11, No. 20. pp. 4341-9.

Bibtex

@article{e37fa9106e8e11df928f000ea68e967b,
title = "Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues",
abstract = "2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid (1) is a potent AMPA receptor agonist with moderate affinity for native kainic acid (KA) receptors, whereas (S)-E-4-(2,2-dimethylpropylidene)glutamic acid (3) show high affinity for the GluR5 subtype of KA receptors and much lower affinity for the GluR2 subtype of AMPA receptors. As an attempt to develop new pharmacological tools for studies of GluR5 receptors, (S)-E-4-(2-thiazolylmethylene)glutamic acid (4a) was designed as a structural hybrid between 1 and 3. 4a was shown to be a potent GluR5 agonist and a high affinity ligand and to indiscriminately bind to the AMPA receptor subtypes GluR1-4 with lower affinities. Compounds 4b-h, in which the 2-thiazolyl substituent of 4a was replaced by other heterocyclic rings, which have previously been incorporated as 5-substituents in AMPA analogues, as exemplified by 1 were also synthesized. Compounds 4b-h were either inactive (4e,f) or weaker than 4a as affinity ligands for GluR1-4 and GluR5 with relative potencies comparable with those of the corresponding AMPA analogues as AMPA receptor agonists. Compounds 4a-h may be useful tools for the progressing pharmacophore mapping of the GluR5 agonist binding site.",
author = "Jon Valgeirsson and Christensen, {Jeppe K} and Kristensen, {Anders S} and Pickering, {Darryl S} and Birgitte Nielsen and Christina Fischer and Hans Br{\"a}uner-Osborne and Nielsen, {Elsebet {\O}} and Povl Krogsgaard-Larsen and Ulf Madsen",
note = "Keywords: Animals; Cell Line; Cerebellar Cortex; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; Ligands; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Substrate Specificity; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid",
year = "2003",
language = "English",
volume = "11",
pages = "4341--9",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "20",

}

RIS

TY - JOUR

T1 - Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues

AU - Valgeirsson, Jon

AU - Christensen, Jeppe K

AU - Kristensen, Anders S

AU - Pickering, Darryl S

AU - Nielsen, Birgitte

AU - Fischer, Christina

AU - Bräuner-Osborne, Hans

AU - Nielsen, Elsebet Ø

AU - Krogsgaard-Larsen, Povl

AU - Madsen, Ulf

N1 - Keywords: Animals; Cell Line; Cerebellar Cortex; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; Ligands; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Substrate Specificity; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

PY - 2003

Y1 - 2003

N2 - 2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid (1) is a potent AMPA receptor agonist with moderate affinity for native kainic acid (KA) receptors, whereas (S)-E-4-(2,2-dimethylpropylidene)glutamic acid (3) show high affinity for the GluR5 subtype of KA receptors and much lower affinity for the GluR2 subtype of AMPA receptors. As an attempt to develop new pharmacological tools for studies of GluR5 receptors, (S)-E-4-(2-thiazolylmethylene)glutamic acid (4a) was designed as a structural hybrid between 1 and 3. 4a was shown to be a potent GluR5 agonist and a high affinity ligand and to indiscriminately bind to the AMPA receptor subtypes GluR1-4 with lower affinities. Compounds 4b-h, in which the 2-thiazolyl substituent of 4a was replaced by other heterocyclic rings, which have previously been incorporated as 5-substituents in AMPA analogues, as exemplified by 1 were also synthesized. Compounds 4b-h were either inactive (4e,f) or weaker than 4a as affinity ligands for GluR1-4 and GluR5 with relative potencies comparable with those of the corresponding AMPA analogues as AMPA receptor agonists. Compounds 4a-h may be useful tools for the progressing pharmacophore mapping of the GluR5 agonist binding site.

AB - 2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid (1) is a potent AMPA receptor agonist with moderate affinity for native kainic acid (KA) receptors, whereas (S)-E-4-(2,2-dimethylpropylidene)glutamic acid (3) show high affinity for the GluR5 subtype of KA receptors and much lower affinity for the GluR2 subtype of AMPA receptors. As an attempt to develop new pharmacological tools for studies of GluR5 receptors, (S)-E-4-(2-thiazolylmethylene)glutamic acid (4a) was designed as a structural hybrid between 1 and 3. 4a was shown to be a potent GluR5 agonist and a high affinity ligand and to indiscriminately bind to the AMPA receptor subtypes GluR1-4 with lower affinities. Compounds 4b-h, in which the 2-thiazolyl substituent of 4a was replaced by other heterocyclic rings, which have previously been incorporated as 5-substituents in AMPA analogues, as exemplified by 1 were also synthesized. Compounds 4b-h were either inactive (4e,f) or weaker than 4a as affinity ligands for GluR1-4 and GluR5 with relative potencies comparable with those of the corresponding AMPA analogues as AMPA receptor agonists. Compounds 4a-h may be useful tools for the progressing pharmacophore mapping of the GluR5 agonist binding site.

M3 - Journal article

C2 - 13129570

VL - 11

SP - 4341

EP - 4349

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 20

ER -

ID: 20122611