Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)
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This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
|Journal||Bioorganic & Medicinal Chemistry Letters|
|Number of pages||4|
|Publication status||Published - 1 Sep 2009|
- Allosteric Regulation/drug effects, Allosteric Site, Anilides/chemical synthesis, Animals, Cyclohexanecarboxylic Acids/chemical synthesis, Disease Models, Animal, Parkinson Disease/drug therapy, Rats, Receptors, Metabotropic Glutamate/chemistry, Structure-Activity Relationship