Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Research output: Contribution to journalJournal articleResearchpeer-review

Richard Williams, Kari A Johnson, Patrick R Gentry, Colleen M Niswender, Charles D Weaver, P Jeffrey Conn, Craig W Lindsley, Corey R Hopkins

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.

Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume19
Issue number17
Pages (from-to)4967-70
Number of pages4
ISSN0960-894X
DOIs
Publication statusPublished - 1 Sep 2009
Externally publishedYes

    Research areas

  • Allosteric Regulation/drug effects, Allosteric Site, Anilides/chemical synthesis, Animals, Cyclohexanecarboxylic Acids/chemical synthesis, Disease Models, Animal, Parkinson Disease/drug therapy, Rats, Receptors, Metabotropic Glutamate/chemistry, Structure-Activity Relationship

ID: 213627573