Synthesis and SAR study of a novel series of dopamine receptor agonists
Research output: Contribution to journal › Journal article › Research › peer-review
R. Risgaard, M. Jensen, M. Jørgensen, B. Bang-Andersen, C.T. Christoffersen, Klaus Gervig Jensen, Jesper Langgaard Kristensen, A. Püschl
The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D and D receptors. This series was designed from pergolide and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-ol (PHBQ) and resulted in the synthesis of (2R,4aR,10aR)-2-methylsulfanylmethyl-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-9-ol (compound 27), which has a D and D receptor profile similar to that of the most recently approved drug for Parkinson's disease, rotigotine.
|Journal||Bioorganic and Medicinal Chemistry|
|Publication status||Published - 1 Jan 2014|