Synthesis of enantiopure 3-substituted morpholines

Research output: Contribution to journalJournal articleResearchpeer-review

Jan Bornholdt, Jakob Felding, Jesper Langgaard Kristensen

Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
Original languageEnglish
JournalJournal of Organic Chemistry
Volume75
Issue number21
Pages (from-to)7454-7457
ISSN0022-3263
DOIs
Publication statusPublished - 2010

ID: 22796243