Synthesis of enantiopure 3-substituted morpholines
Research output: Contribution to journal › Journal article › Research › peer-review
Jan Bornholdt, Jakob Felding, Jesper Langgaard Kristensen
Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 2010|
- The Faculty of Pharmaceutical Sciences