Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Søren W Pedersen, Christopher J Armishaw, Kristian Strømgaard
The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.
|Title of host publication||Peptide synthesis and applications|
|Number of pages||16|
|Publication status||Published - 2013|
|Series||Methods in Molecular Biology|