Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Søren W Pedersen, Christopher J Armishaw, Kristian Strømgaard

The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.
Original languageEnglish
Title of host publicationPeptide synthesis and applications
Number of pages16
Volume1047
PublisherHumana Press
Publication date2013
Pages65-80
ISBN (Electronic)978-1-62703-544-6
DOIs
Publication statusPublished - 2013
SeriesMethods in Molecular Biology
ISSN1064-3745

ID: 100049878