Employees – University of Copenhagen

The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

Research output: Contribution to journalJournal articleResearchpeer-review

Sanne Gottschalk, Dan Ifrah, Sandra Lerche Søndergaard, Caroline Trebbien Gottlieb, Marianne Thorup Cohn, Hiroshi Hiasa, Paul Robert Hansen, Lone Gram, Hanne Ingmer, Line Elnif Thomsen

The increase in antibiotic resistant bacteria has led to renewed interest in development of alternative antimicrobial compounds such as antimicrobial peptides (AMPs), either naturally-occurring or synthetically-derived. Knowledge of the mode of action (MOA) of synthetic compounds mimicking the function of AMPs is highly valuable both when developing new types of antimicrobials and when predicting resistance development. Despite many functional studies of AMPs, only a few of the synthetic peptides have been studied in detail.
Original languageEnglish
Article number192
JournalB M C Microbiology
Volume13
Number of pages8
ISSN1471-2180
DOIs
Publication statusPublished - 2013

ID: 49604868