The calcium-sensing receptor and calcimimetics in blood pressure modulation

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The calcium-sensing receptor and calcimimetics in blood pressure modulation. / Smajilovic, Sanela; Yano, Shozo; Jabbari, Reza; Tfelt-Hansen, Jacob.

In: British Journal of Pharmacology, Vol. 164, No. 3, 10.2011, p. 884-893.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Smajilovic, S, Yano, S, Jabbari, R & Tfelt-Hansen, J 2011, 'The calcium-sensing receptor and calcimimetics in blood pressure modulation', British Journal of Pharmacology, vol. 164, no. 3, pp. 884-893. https://doi.org/10.1111/j.1476-5381.2011.01317.x

APA

Smajilovic, S., Yano, S., Jabbari, R., & Tfelt-Hansen, J. (2011). The calcium-sensing receptor and calcimimetics in blood pressure modulation. British Journal of Pharmacology, 164(3), 884-893. https://doi.org/10.1111/j.1476-5381.2011.01317.x

Vancouver

Smajilovic S, Yano S, Jabbari R, Tfelt-Hansen J. The calcium-sensing receptor and calcimimetics in blood pressure modulation. British Journal of Pharmacology. 2011 Oct;164(3):884-893. https://doi.org/10.1111/j.1476-5381.2011.01317.x

Author

Smajilovic, Sanela ; Yano, Shozo ; Jabbari, Reza ; Tfelt-Hansen, Jacob. / The calcium-sensing receptor and calcimimetics in blood pressure modulation. In: British Journal of Pharmacology. 2011 ; Vol. 164, No. 3. pp. 884-893.

Bibtex

@article{75d00d44f6854fa980bc38cd4b49dcd0,
title = "The calcium-sensing receptor and calcimimetics in blood pressure modulation",
abstract = "Calcium is a crucial second messenger in the cardiovascular system. However, calcium may also be an extracellular first messenger through a G-protein-coupled receptor that senses extracellular concentration (Ca(2+)(o)), the calcium-sensing receptor (CaR). The most prominent physiological function of the CaR is to maintain the extracellular Ca(2+) level in a very tight range by regulating the circulating levels of parathyroid hormone (PTH). This control over PTH and Ca(2+) levels is partially lost in patients suffering from primary and secondary hyperparathyroidism. Allosteric modulators of the CaR (calcimimetics) are the first drugs in their class to become available for clinical use and have been shown to successfully treat certain forms of primary and secondary hyperparathyroidism. In addition, several studies suggest beneficial effects of calcimimetics on cardiovascular risk factors associated with hyperparathyroidism. Although a plethora of studies demonstrated the CaR in heart and blood vessels, exact roles of the receptor in the cardiovascular system still remain to be elucidated. However, several studies point toward a possibility that the CaR might be involved in the regulation of vascular tone. This review will summarize the current knowledge on the possible functions of the CaR and calcimimetics on blood pressure regulation.",
keywords = "The Faculty of Health and Medical Sciences, The Faculty of Pharmaceutical Sciences",
author = "Sanela Smajilovic and Shozo Yano and Reza Jabbari and Jacob Tfelt-Hansen",
note = "This article is part of a themed issue on Vascular Endothelium in Health and Disease. Keywords: calcium-sensing receptor; G-protein; seven-transmembrane receptor; vascular tone; calcimimetics",
year = "2011",
month = "10",
doi = "10.1111/j.1476-5381.2011.01317.x",
language = "English",
volume = "164",
pages = "884--893",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - The calcium-sensing receptor and calcimimetics in blood pressure modulation

AU - Smajilovic, Sanela

AU - Yano, Shozo

AU - Jabbari, Reza

AU - Tfelt-Hansen, Jacob

N1 - This article is part of a themed issue on Vascular Endothelium in Health and Disease. Keywords: calcium-sensing receptor; G-protein; seven-transmembrane receptor; vascular tone; calcimimetics

PY - 2011/10

Y1 - 2011/10

N2 - Calcium is a crucial second messenger in the cardiovascular system. However, calcium may also be an extracellular first messenger through a G-protein-coupled receptor that senses extracellular concentration (Ca(2+)(o)), the calcium-sensing receptor (CaR). The most prominent physiological function of the CaR is to maintain the extracellular Ca(2+) level in a very tight range by regulating the circulating levels of parathyroid hormone (PTH). This control over PTH and Ca(2+) levels is partially lost in patients suffering from primary and secondary hyperparathyroidism. Allosteric modulators of the CaR (calcimimetics) are the first drugs in their class to become available for clinical use and have been shown to successfully treat certain forms of primary and secondary hyperparathyroidism. In addition, several studies suggest beneficial effects of calcimimetics on cardiovascular risk factors associated with hyperparathyroidism. Although a plethora of studies demonstrated the CaR in heart and blood vessels, exact roles of the receptor in the cardiovascular system still remain to be elucidated. However, several studies point toward a possibility that the CaR might be involved in the regulation of vascular tone. This review will summarize the current knowledge on the possible functions of the CaR and calcimimetics on blood pressure regulation.

AB - Calcium is a crucial second messenger in the cardiovascular system. However, calcium may also be an extracellular first messenger through a G-protein-coupled receptor that senses extracellular concentration (Ca(2+)(o)), the calcium-sensing receptor (CaR). The most prominent physiological function of the CaR is to maintain the extracellular Ca(2+) level in a very tight range by regulating the circulating levels of parathyroid hormone (PTH). This control over PTH and Ca(2+) levels is partially lost in patients suffering from primary and secondary hyperparathyroidism. Allosteric modulators of the CaR (calcimimetics) are the first drugs in their class to become available for clinical use and have been shown to successfully treat certain forms of primary and secondary hyperparathyroidism. In addition, several studies suggest beneficial effects of calcimimetics on cardiovascular risk factors associated with hyperparathyroidism. Although a plethora of studies demonstrated the CaR in heart and blood vessels, exact roles of the receptor in the cardiovascular system still remain to be elucidated. However, several studies point toward a possibility that the CaR might be involved in the regulation of vascular tone. This review will summarize the current knowledge on the possible functions of the CaR and calcimimetics on blood pressure regulation.

KW - The Faculty of Health and Medical Sciences

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1111/j.1476-5381.2011.01317.x

DO - 10.1111/j.1476-5381.2011.01317.x

M3 - Review

VL - 164

SP - 884

EP - 893

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 3

ER -

ID: 38098775